Alpk2 Gene Summary [Mouse]
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Predicted to act upstream of or within regulation of gene expression. Predicted to colocalize with basolateral plasma membrane. Orthologous to human ALPK2 (alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alpk2 |
| Official Name | alpha-kinase 2 [Source:MGI Symbol;Acc:MGI:2449492] |
| Ensembl ID | ENSMUSG00000032845 |
| Bio databases IDs | |
| Aliases | alpha-kinase 2 |
| Synonyms | alpha-kinase 2, Gm549, HAK, RGD1564431, α-kinase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alpk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Alpha kinase family
- protein serine/threonine kinase
- catalytic domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Alpha-kinase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
- bladder cancer
- congenital posterior urethral valve disorder
- Alzheimer disease
- multiple sclerosis
- diastolic dysfunction
- idiopathic scoliosis
role in cell
- apoptosis
- phosphorylation in
- survival
- development
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alpk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart morphogenesis
- negative regulation of Wnt receptor signaling pathway involved in heart development
- cardiac muscle cell development
- regulation of gene expression
- establishment of cell polarity
- regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity