Psmc3ip Gene Summary [Mouse]
Predicted to enable several functions, including DNA binding domain binding activity; nuclear receptor binding activity; and recombinase activator activity. Predicted to be involved in meiosis I and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase auxiliary factor complex. Predicted to be active in condensed nuclear chromosome. Is expressed in metanephros; submandibular gland primordium; telencephalon ventricular layer; tooth; and vibrissa. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmc3ip |
| Official Name | proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein [Source:MGI Symbol;Acc:MGI:1098610] |
| Ensembl ID | ENSMUSG00000019303 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein |
| Synonyms | GT198, HOP2, HUMGT198A, ODG3, proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein, PSMC3 interacting protein, Tat-binding interacting, TBPIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmc3ip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- DBD domain binding
- androgen receptor binding
- leucine zipper domain
- coiled-coil domain
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- identical protein binding
- binding protein
- TBPIP/Hop2 winged helix domain
- retinoid X receptor binding
- basic domain
- Leucine zipper with capping helix domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infertility condition
- ovarian dysgenesis type 3
- hypoplasia
- azoospermia
- uterine leiomyoma
- leiomyomatosis
phenotypes
- abnormal male meiosis
- abnormal meiosis
- abnormal ovary development
- absent gametes
- absent ovarian follicles
- arrest of male meiosis
- azoospermia
- infertility
- testis hypoplasia
role in cell
- expression in
- differentiation
- talazoparib sensitivity
- olaparib sensitivity
- transcription in
- self-renewal capacity
- binding in
- cell survival
- synapsis in
- homologous recombination repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmc3ip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic joint molecule formation
- reciprocal meiotic recombination
- positive regulation of transcription, DNA-dependent
- synapsis
- meiotic strand invasion involved in reciprocal meiotic recombination
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity
- double-stranded DNA binding