Rhbdd3 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including MAPK cascade; negative regulation of natural killer cell activation; and positive regulation of protein catabolic process. Predicted to be located in membrane. Orthologous to human RHBDD3 (rhomboid domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhbdd3 |
| Official Name | rhomboid domain containing 3 [Source:MGI Symbol;Acc:MGI:2444684] |
| Ensembl ID | ENSMUSG00000034175 |
| Bio databases IDs | |
| Aliases | rhomboid domain containing 3 |
| Synonyms | C22orf3, HS984G1A, LOC108167339, PTAG, RGD1311827, rhomboid domain containing 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhbdd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute inflammation
role in cell
- morphology
- expression in
- activation in
- number
- function
- degradation in
- activation
- cytolysis by
- replication in
- interaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhbdd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- negative regulation of natural killer cell activation
- regulation of protein secretion
- liver development
- positive regulation of protein catabolic process
- response to xenobiotic stimulus
- regulation of acute inflammatory response
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity