Dgkh Gene Summary [Mouse]
Enables ATP-dependent diacylglycerol kinase activity. Involved in diacylglycerol metabolic process; lipid phosphorylation; and phosphatidic acid biosynthetic process. Located in actin cytoskeleton; cytoplasm; and plasma membrane. Is expressed in nervous system and neural retina. Orthologous to human DGKH (diacylglycerol kinase eta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgkh |
| Official Name | diacylglycerol kinase, eta [Source:MGI Symbol;Acc:MGI:2444188] |
| Ensembl ID | ENSMUSG00000034731 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase, eta |
| Synonyms | 5930402B05RIK, D130015C16, DGK, DGKeta, diacylglycerol kinase eta, diacylglycerol kinase, eta, LOC283508, RGD1561955 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgkh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- diacylglycerol kinase
- SAM (Sterile alpha motif )
- SAM domain
- protein domain specific binding
- Pleckstrin homology-like domain
- identical protein binding
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- Sterile alpha motif
- kinase binding
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- SAM domain (Sterile alpha motif)
- protein homodimerization
- PH domain
- Diacylglycerol kinase catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- hyperactive behavior
- kidney stones
- bipolar disorder
- urolithiasis
- urinary bladder stone
- colorectal cancer
role in cell
- expression in
- differentiation
- proliferation
- activation in
- growth
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- actin cytoskeleton
- Plasma Membrane
- endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgkh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidic acid metabolic process
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- lipid phosphorylation
- phosphatidic acid biosynthetic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- intracellular membrane-bounded organelle
- actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- diacylglycerol kinase activity