Sncb Gene Summary [Mouse]
Predicted to enable metal ion binding activity and tubulin binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; dopamine metabolic process; and negative regulation of neuron apoptotic process. Located in synapse. Is expressed in central nervous system; peripheral nervous system; retina; stomach; and testis. Human ortholog(s) of this gene implicated in Lewy body dementia and Parkinson's disease. Orthologous to human SNCB (synuclein beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sncb |
| Official Name | synuclein, beta [Source:MGI Symbol;Acc:MGI:1889011] |
| Ensembl ID | ENSMUSG00000034891 |
| Bio databases IDs | |
| Aliases | synuclein, beta |
| Synonyms | betaSYN, Beta Synuclein, Synuclein Beta, synuclein, beta, Synuclein β, synuclein, β, β Synuclein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sncb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- copper ion binding
- alpha-tubulin binding
- phospholipase inhibitor
- calcium ion binding
- Synuclein
- protein binding
- transition metal ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lewy body disease
- schizophrenia
- Parkinson disease
- neurodegeneration
- Parkinson disease with dementia
role in cell
- apoptosis
- quantity
- formation
- survival
- morphology
- size
- endocytosis
- formation in
- organization
- fibrillogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- intracellular space
- microtubules
- cytosol
- growth cone
- synapse
- perikaryon
- axons
- axon terminals
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sncb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine metabolic process
- synaptic vesicle endocytosis
- synapse organization
- synaptic transmission
- neuron apoptotic process
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- neuronal cell body
- inclusion body
- axon terminus
Molecular Function
What the gene product does at the molecular level
- transition metal ion binding
- protein binding
- calcium ion binding
- phospholipase inhibitor activity