Tab3 Gene Summary [Mouse]
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in defense response to bacterium; non-canonical NF-kappaB signal transduction; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adrenal gland; gonad; liver; lung; and spleen. Orthologous to human TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tab3 |
| Official Name | TGF-beta activated kinase 1/MAP3K7 binding protein 3 [Source:MGI Symbol;Acc:MGI:1913974] |
| Ensembl ID | ENSMUSG00000035476 |
| Bio databases IDs | |
| Aliases | TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
| Synonyms | 4921526G09RIK, MAP3K7IP3, mKIAA4135, NAP1, TGF-beta activated kinase 1 (MAP3K7) binding protein 3, TGF-beta activated kinase 1/MAP3K7 binding protein 3, TGF-β activated kinase 1 (MAP3K7) binding protein 3, TGF-β activated kinase 1/MAP3K7 binding protein 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tab3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Zn-finger in Ran binding protein and others
- zinc ion binding
- coiled-coil domain
- protein binding
- zinc finger domain
Pathways
Biological processes and signaling networks where the Tab3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic carcinoma
role in cell
- activation
- activation in
- proliferation
- development
- transformation
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tab3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of autophagy
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- NIK/NF-kappaB cascade
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- endosome membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ubiquitin binding
- K63-linked polyubiquitin binding
- binding, bridging