Dock4 Gene Summary [Mouse]
Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in cell chemotaxis; negative regulation of vascular associated smooth muscle contraction; and positive regulation of vascular associated smooth muscle cell migration. Located in stereocilium. Is expressed in dorsal aorta; ovary; and testis. Orthologous to human DOCK4 (dedicator of cytokinesis 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dock4 |
| Official Name | dedicator of cytokinesis 4 [Source:MGI Symbol;Acc:MGI:1918006] |
| Ensembl ID | ENSMUSG00000035954 |
| Bio databases IDs | |
| Aliases | dedicator of cytokinesis 4 |
| Synonyms | 5330406C03, 6330411N01RIK, AF263288, C030023J22, dedicator of cytokinesis 4, mKIAA0716, RGD1563407 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dock4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHR-2, Lobe B
- C2 domain in Dock180 and Zizimin proteins
- DOCK homology region 1
- DHR-2, Lobe A
- enzyme binding
- DOCK N-terminus
- protein binding
- proline rich domain
- PDZ-domain binding
- Src Homology 3 domain superfamily
- Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
- receptor tyrosine kinase binding
- DOCK homology region 2
- guanyl-nucleotide exchange factor
- C2 domain
- DHR-2, Lobe C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- lung adenocarcinoma formation
- COVID-19
- astigmatism
- insomnia
- neurodevelopmental disorder
- Alzheimer disease
- placenta accreta spectrum
- ankylosing spondylitis
role in cell
- activation in
- phosphorylation in
- invasion by
- formation
- migration
- differentiation
- arborization
- colony formation
- chemotaxis
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- cytosol
- stereocilia
- nucleoli
- perinuclear vesicles
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dock4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- stereocilium bundle
- cytosol
- Golgi apparatus
- stereocilium
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- PDZ domain binding
- small GTPase binding
- SH3 domain binding
- receptor tyrosine kinase binding