Ndufa13 Gene Summary [Mouse]
Predicted to enable ATP binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in mitochondrion and nucleus. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; heart; and oocyte. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and oncocytic carcinoma of the thyroid. Orthologous to human NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufa13 |
| Official Name | NADH:ubiquinone oxidoreductase subunit A13 [Source:MGI Symbol;Acc:MGI:1914434] |
| Ensembl ID | ENSMUSG00000036199 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit A13 |
| Synonyms | 2700054G14Rik, B16.6, CDA016, CGI-39, CI-B16.6, GRIM-19, HCC, MC1DN28, NADH:ubiquinone oxidoreductase subunit A13, Ndufa13-ps |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndufa13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GRIM-19 protein
- ATP-binding domain
- ATP binding
- enzyme
- helix-loop-helix domain
- protein binding
Pathways
Biological processes and signaling networks where the Ndufa13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- thyroid oncocytic carcinoma
- Parkinson disease
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- nuclear type 28 mitochondrial complex I deficiency
- Mitochondrial complex I deficiency
- neoplastic cell transformation
- adult acute myeloid leukemia
role in cell
- apoptosis
- proliferation
- cell viability
- expression in
- production in
- phosphorylation in
- molecular cleavage in
- growth
- cell death
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Nucleus
- Mitochondria
- granules
- mitochondrial membrane
- mitochondrial inner membrane
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndufa13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extrinsic apoptotic signaling pathway
- apoptotic signaling pathway
- protein import into mitochondrial inner membrane
- positive regulation of protein catabolic process
- mitochondrial ATP synthesis coupled proton transport
- positive regulation of execution phase of apoptosis
- reactive oxygen species metabolic process
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- cellular response to retinoic acid
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- negative regulation of intrinsic apoptotic signaling pathway
- cellular response to interferon-beta
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial membrane
- mitochondrial respiratory chain
- cytoplasm
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- ATP binding
- protein binding