Nsg1 Gene Summary [Mouse]
Predicted to enable clathrin light chain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including amyloid precursor protein metabolic process; neurotransmitter receptor transport; and receptor recycling. Located in late endosome; lateral plasma membrane; and postsynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system ganglion; and sensory organ. Orthologous to human NSG1 (neuronal vesicle trafficking associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsg1 |
| Official Name | neuron specific gene family member 1 [Source:MGI Symbol;Acc:MGI:109149] |
| Ensembl ID | ENSMUSG00000029126 |
| Bio databases IDs | |
| Aliases | neuron specific gene family member 1 |
| Synonyms | Brain neuron cytoplasmic protein 1, Brain neuron cytoplasmic protein 2, BSMRB, D4S234, D4S234E, LOC105374360, m234, NEEP21, neuronal vesicle trafficking associated 1, neuron specific gene family member 1, P21, PEP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nsg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- D1 dopamine receptor-interacting protein (calcyon)
- protein binding
- receptor binding
- ionotropic glutamate receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- breast cancer
- bacterial meningitis
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- organismal death
- coronary artery disease
- tuberculosis
role in cell
- production in
- apoptosis
- proliferation
- expression in
- colony formation
- migration
- thickness
- growth
- transport
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- somatodendritic region
- perinuclear region
- Nucleus
- Plasma Membrane
- endosomes
- Endoplasmic Reticulum
- postsynaptic membrane
- lateral plasma membrane
- Golgi membrane
- trans Golgi network
- lysosomal compartment
- endosomal membrane
- neurites
- dendritic trees
- early endosomes
- late endosomes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nsg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of long-term synaptic potentiation
- positive regulation of receptor recycling
- clathrin coat assembly
- apoptotic process
- dopamine receptor signaling pathway
- endosomal transport
- amyloid precursor protein metabolic process
- receptor recycling
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- Golgi cisterna membrane
- late endosome
- lysosomal lumen
- endoplasmic reticulum
- early endosome membrane
- endoplasmic reticulum membrane
- dendrite
- nucleus
- endosome
- cytoplasm
- postsynaptic membrane
- membrane
- recycling endosome membrane
- multivesicular body membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- clathrin light chain binding
- ionotropic glutamate receptor binding
- protein binding