Cblb Gene Summary [Mouse]
Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway; regulation of postsynaptic neurotransmitter receptor internalization; and regulation protein catabolic process at postsynapse. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cblb |
| Official Name | Casitas B-lineage lymphoma b [Source:MGI Symbol;Acc:MGI:2146430] |
| Ensembl ID | ENSMUSG00000022637 |
| Bio databases IDs | |
| Aliases | Casitas B-lineage lymphoma b |
| Synonyms | ADMIO3, Casitas B-lineage lymphoma b, Cbl proto-oncogene B, Nbla00127, RNF56 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cblb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- proline glycine arginine motif
- protein kinase binding
- CBL proto-oncogene N-terminal domain 1
- tyrosine kinase binding domain
- pro-x-x-x-pro-arg motif
- leucine zipper domain
- enzyme
- protein binding
- phosphotyrosine binding domain
- acidic domain
- Cbl homology domain
- proline rich domain
- arginine proline-rich domain
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Src homology 2 (SH2) domain
- zinc finger domain
- CBL proto-oncogene N-terminus, EF hand-like domain
- CBL proto-oncogene N-terminus, SH2-like domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Cblb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- neoplasia
- cancer
- myeloproliferative disorder
- epithelial cancer
- abdominal cancer
- liver cancer
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- apoptosis
- cell death
- expression in
- production in
- proliferation
- survival
- activation in
- phosphorylation in
- disruption
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cblb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epidermal growth factor-activated receptor activity
- signal transduction
- protein catabolic process
- positive regulation of protein catabolic process
- T cell anergy
- immune response
- negative regulation of T cell receptor signaling pathway
- positive regulation of T cell anergy
- CD4-positive, alpha-beta T cell proliferation
- NLS-bearing substrate import into nucleus
- positive regulation of protein ubiquitination
- regulation of platelet-derived growth factor receptor-alpha signaling pathway
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- intracellular signal transduction
- T cell receptor signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- membrane raft
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- zinc ion binding
- protein binding
- calcium ion binding
- SH3 domain binding
- receptor tyrosine kinase binding