Psenen Gene Summary [Mouse]
Enables endopeptidase activator activity. Involved in positive regulation of endopeptidase activity and protein processing. Acts upstream of or within Notch receptor processing. Part of gamma-secretase complex. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psenen |
| Official Name | presenilin enhancer gamma secretase subunit [Source:MGI Symbol;Acc:MGI:1913590] |
| Ensembl ID | ENSMUSG00000036835 |
| Bio databases IDs | |
| Aliases | presenilin enhancer gamma secretase subunit |
| Synonyms | 1700023M09RIK, ACNINV2, MDS033, MSTP064, PEN-2, presenilin enhancer gamma secretase subunit, presenilin enhancer, gamma-secretase subunit, presenilin enhancer γ secretase subunit, presenilin enhancer, γ-secretase subunit, RGD1312037 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psenen often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- transmembrane domain
- enzyme binding
- enzyme
- protein binding
- enzyme regulator activity
- Presenilin enhancer-2 subunit of gamma secretase
- protease activator
Pathways
Biological processes and signaling networks where the Psenen gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- ErbB4 Signaling
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Neuroinflammation Signaling Pathway
- Notch Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial acne inversa type 2
- familial acne inversa type 2 with Dowling-Degos disease
- familial acne inversa type 2 without Dowling-Degos disease
role in cell
- apoptosis
- production in
- dipeptide repeat protein sensitivity
- molecular cleavage in
- endoproteolysis in
- replication in
- proteolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- membrane fraction
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- presynaptic membrane
- endosomal membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psenen gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amyloid precursor protein catabolic process
- Notch signaling pathway
- membrane protein ectodomain proteolysis
- Notch receptor processing
- membrane protein intracellular domain proteolysis
- protein processing
- amyloid precursor protein metabolic process
- positive regulation of endopeptidase activity
- beta-amyloid formation
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- endoplasmic reticulum membrane
- Golgi cisterna membrane
- membrane
- gamma-secretase complex
- Golgi membrane
- endoplasmic reticulum
- endosome membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- protein binding
- enzyme binding