Arid5a Gene Summary [Mouse]
Enables RNA stem-loop binding activity and chromatin binding activity. Involved in cellular response to lipopolysaccharide; positive regulation of T-helper 17 type immune response; and positive regulation of cytokine production. Acts upstream of or within chondrocyte differentiation; positive regulation of protein acetylation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including ear; heart; hemolymphoid system; nervous system; and neural retina. Orthologous to human ARID5A (AT-rich interaction domain 5A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arid5a |
| Official Name | AT rich interactive domain 5A (MRF1-like) [Source:MGI Symbol;Acc:MGI:2443039] |
| Ensembl ID | ENSMUSG00000037447 |
| Bio databases IDs | |
| Aliases | AT rich interactive domain 5A (MRF1-like) |
| Synonyms | AT-rich interaction domain 5A, D430024K22Rik, LOC100132284, LOC100996535, MRF-1, RP11-363D14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arid5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- androgen receptor binding
- transcription factor binding
- chromatin binding
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- sequence-specific DNA binding
- identical protein binding
- ARID/BRIGHT DNA binding domain
- DNA binding
- RNA binding
- mRNA 3' UTR binding
- retinoid X receptor binding
- ARID/BRIGHT DNA binding domain family
Pathways
Biological processes and signaling networks where the Arid5a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- obesity
- acute myeloid leukemia
- focal segmental glomerulosclerosis
- lupus erythematosus
- autoimmune glomerulonephritis
- experimental autoimmune encephalomyelitis
- ANCA disease
- endotoxin shock response
- membranous glomerulonephritis
role in cell
- expression in
- activation in
- acetylation in
- differentiation
- number
- cellular infiltration by
- stabilization in
- transactivation in
- transcription in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- granules
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arid5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondrocyte differentiation
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to estrogen stimulus
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of T-helper 17 type immune response
- cellular response to lipopolysaccharide
- negative regulation of transcription, DNA-dependent
- innate immune response
- positive regulation of interferon-gamma production
- positive regulation of interleukin-17 production
- positive regulation of tumor necrosis factor production
- positive regulation of T-helper 1 cell cytokine production
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- chromatin binding
- transcription factor binding
- retinoid X receptor binding
- thyroid hormone receptor binding
- DNA binding
- protein binding
- androgen receptor binding
- transcription corepressor activity
- RNA stem-loop binding
- estrogen receptor binding