Nop56 Gene Summary [Mouse]
Enables RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in fibrillar center. Predicted to be part of box C/D methylation guide snoRNP complex; pre-snoRNP complex; and small-subunit processome. Is expressed in alimentary system; central nervous system; liver; metanephros; and retina nuclear layer. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nop56 |
| Official Name | NOP56 ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1914384] |
| Ensembl ID | ENSMUSG00000027405 |
| Bio databases IDs | |
| Aliases | NOP56 ribonucleoprotein |
| Synonyms | 2310044F10Rik, NOL5A, NOP56 ribonucleoprotein, SCA36 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nop56 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NOP5NT (NUC127) domain
- snoRNA binding domain, fibrillarin
- enzyme binding
- snoRNA binding
- protein binding
- NOSIC (NUC001) domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric adenocarcinoma
- gastric epithelial cancer
- plexiform neurofibroma
- spinocerebellar ataxia type 36
- infection by vesicular stomatitis virus
regulates
- reactive oxygen species
role in cell
- sirolimus sensitivity
- processing in
- everolimus sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- fibrillar center
- pre-ribosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nop56 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit biogenesis
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- box C/D snoRNP complex
- small-subunit processome
- cytoplasm
- pre-snoRNP complex
- membrane
- nucleolus
- small nucleolar ribonucleoprotein complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- snoRNA binding
- RNA binding
- cadherin binding