P3h2 Gene Summary [Mouse]
Predicted to enable procollagen-proline 3-dioxygenase activity. Predicted to be involved in collagen metabolic process; negative regulation of cell population proliferation; and peptidyl-proline hydroxylation. Located in basement membrane. Is expressed in several structures, including central nervous system; limb bud; musculoskeletal system; renal cortex; and sensory organ. Orthologous to human P3H2 (prolyl 3-hydroxylase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | P3h2 |
| Official Name | prolyl 3-hydroxylase 2 [Source:MGI Symbol;Acc:MGI:2146663] |
| Ensembl ID | ENSMUSG00000038168 |
| Bio databases IDs | |
| Aliases | prolyl 3-hydroxylase 2 |
| Synonyms | 4832416N06, LEPREL1, LOC102554639, MCVD, MLAT4, prolyl 3-hydroxylase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse P3h2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- procollagen-proline 3-dioxygenase
- enzyme
- 2OG-Fe(II) oxygenase superfamily
- Prolyl 4-hydroxylase alpha subunit homologues
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- high myopia with cataract and vitreoretinal degeneration
- breast carcinoma
- heart septal defect
- peripheral arterial disease
- early-onset high myopia
- hip osteoarthritis
- osteoarthritis
- thrombocytopenia
- retinitis pigmentosa
- myopia
role in cell
- proliferation
- 3-hydroxylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum lumen
- nucleoplasm
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse P3h2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- peptidyl-proline hydroxylation
- collagen metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- basement membrane
- sarcoplasmic reticulum
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- L-ascorbic acid binding
- iron ion binding
- procollagen-proline 3-dioxygenase activity