Afp Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including homeostasis of number of cells; ovulation from ovarian follicle; and progesterone metabolic process. Located in cytoplasm and extracellular space. Is expressed in several structures, including egg cylinder; embryo endoderm; gut; liver and biliary system; and metanephros. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Afp |
| Official Name | alpha fetoprotein [Source:MGI Symbol;Acc:MGI:87951] |
| Ensembl ID | ENSMUSG00000054932 |
| Bio databases IDs | |
| Aliases | alpha fetoprotein |
| Synonyms | AFPD, Alpha fetoprotein, FETA, Fetoprotein α, HPAFP, α 1 fetoprotein, α fetoprotein, α foetoprotein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Afp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ALBUMIN
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- metastasis
- lung cancer
- premature ovarian failure
- hepatocellular carcinoma
- alpha feto-protein deficiency
- liver cancer
- hereditary persistence of alpha-fetoprotein
- gastric cancer
- malignant ovarian germ cell tumor
role in cell
- cell death
- proliferation
- migration
- apoptosis
- growth
- activation
- quantity
- invasion by
- expression in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- endoplasmic reticulum lumen
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Afp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- progesterone metabolic process
- ovulation from ovarian follicle
- transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- small molecule binding