Dido1 Gene Summary [Mouse]
This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | Dido1 |
| Official Name | death inducer-obliterator 1 [Source:MGI Symbol;Acc:MGI:1344352] |
| Ensembl ID | ENSMUSG00000038914 |
| Bio databases IDs | |
| Aliases | death inducer-obliterator 1 |
| Synonyms | 6720461J16Rik, BYE1, C130092D22Rik, C20ORF158, D130048F08Rik, DATF-1, death inducer-obliterator 1, dido, DIO-1, dJ885L7.8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dido1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPOC (Spen paralog and ortholog C-terminal) domain superfamily
- PHD zinc finger
- Transcription factor S-II (TFIIS), central domain
- SPOC domain
- nuclear localization sequence
- PHD finger superfamily
- protein binding
- Transcription factor S-II M domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- cancer
- metabolic syndrome X
- tumorigenesis
- metastasis
- gastric cancer
- hyperplasia
- organismal death
- advanced cancer
role in cell
- expression in
- binding in
- migration
- growth
- proliferation
- apoptosis
- quantity
- number
- invasion by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dido1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- spindle
Molecular Function
What the gene product does at the molecular level
- RNA binding
- metal ion binding