Usp6nl Gene Summary [Mouse]
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including plasma membrane to endosome transport; positive regulation of GTPase activity; and retrograde transport, plasma membrane to Golgi. Predicted to be located in plasma membrane. Predicted to be active in cytoplasmic vesicle. Orthologous to human USP6NL (USP6 N-terminal like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp6nl |
| Official Name | USP6 N-terminal like [Source:MGI Symbol;Acc:MGI:2138893] |
| Ensembl ID | ENSMUSG00000039046 |
| Bio databases IDs | |
| Aliases | USP6 N-terminal like |
| Synonyms | AI316785, mKIAA0019, RNTRE, TRE2NL, USP6NL-IT1, USP6 N-terminal like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp6nl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Domain in Tre-2, BUB2p, and Cdc16p
- enzyme binding
- GTPase activator
Pathways
Biological processes and signaling networks where the Usp6nl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- carcinoma in situ
- epithelial cancer in situ
role in cell
- migration by
- exocytosis by
- organization
- formation
- formation in
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
- membrane ruffles
- trans Golgi network
- cytoplasmic vesicles
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp6nl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi organization
- retrograde transport, plasma membrane to Golgi
- virion assembly
- plasma membrane to endosome transport
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- cytosol
- trans-Golgi network membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- small GTPase binding