Cdc14a Gene Summary [Mouse]
Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Involved in sensory perception of sound. Located in kinociliary basal body and stereocilium tip. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 32. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc14a |
| Official Name | CDC14 cell division cycle 14A [Source:MGI Symbol;Acc:MGI:2442676] |
| Ensembl ID | ENSMUSG00000033502 |
| Bio databases IDs | |
| Aliases | CDC14 cell division cycle 14A |
| Synonyms | A830059A17RIK, CD14, CDC14, CDC14a1, CDC14A2, CDC14 cell division cycle 14A, cell division cycle 14A, DFNB105, DFNB32, DFNB35, hCDC14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc14a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- nuclear export signal
- plk1 phosphorylation site
- protein serine/threonine phosphatase
- phosphatase
- PTP_DSP_cys
- protein binding
- phosphatase domain
- Dual specificity protein phosphatase, N-terminal half
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcoholism
- teratozoospermia
- colorectal carcinomagenesis
- organismal death
- breast adenocarcinoma
- infertile male syndrome with hearing impairment
- autosomal recessive deafness type 105
- diarrhea
- breast carcinoma
- chronic lymphocytic leukemia
role in cell
- expression in
- cell death
- quantity
- length
- phosphorylation in
- growth
- formation
- formation in
- mitosis
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- kinocilia
- Cytoplasm
- actin cytoskeleton
- basal bodies
- centrosome
- Endoplasmic Reticulum
- midbody
- cytosol
- stereocilia
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc14a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- cell division
- cilium morphogenesis
- regulation of exit from mitosis
- microtubule cytoskeleton organization
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- nuclear body
- mitotic spindle
- cytoplasm
- spindle pole
- kinocilium
- cytosol
- nucleolus
- stereocilium bundle tip
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- myosin phosphatase activity