B3galnt2 Gene Summary [Mouse]
Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to act upstream of or within UDP-N-acetylgalactosamine metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in submandibular gland primordium. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A11. Orthologous to human B3GALNT2 (beta-1,3-N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | B3galnt2 |
| Official Name | UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:2145517] |
| Ensembl ID | ENSMUSG00000039242 |
| Bio databases IDs | |
| Aliases | UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 |
| Synonyms | A930105D20Rik, B3GalNAc-T2, beta-1,3-N-acetylgalactosaminyltransferase 2, beta 3 GALNAC-T2, D230016N13Rik, IMAGE:4393885, MDDGA11, RGD1306946, UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2, UDP-GalNAc:betaGlcNAc β 1,3-galactosaminyltransferase, polypeptide 2, β-1,3-N-acetylgalactosaminyltransferase 2, β 3 GALNAC-T2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse B3galnt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylgalactosaminyltransferase
- galactosyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies) type A11
- hereditary disorder
- muscular dystrophy-dystroglycanopathy
regulates
- UDP-N-acetyl-D-galactosamine
- N-acetylglucosamine
role in cell
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse B3galnt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- protein glycosylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- UDP-glycosyltransferase activity
- protein binding
- acetylgalactosaminyltransferase activity