Zfp335 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone methyltransferase binding activity. Involved in brain development; neuron projection morphogenesis; and positive regulation of neuroblast proliferation. Acts upstream of or within several processes, including brain development; in utero embryonic development; and regulation of neurogenesis. Located in nucleus. Part of histone methyltransferase complex. Is expressed in brain and future brain. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp335 |
| Official Name | zinc finger protein 335 [Source:MGI Symbol;Acc:MGI:2682313] |
| Ensembl ID | ENSMUSG00000039834 |
| Bio databases IDs | |
| Aliases | zinc finger protein 335 |
| Synonyms | 1810045J01Rik, LOC102554906, MCPH10, Nif, NIF-1, Zfp335, Zinc finger protein 335 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp335 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- transcription co-activator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- enzyme binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- hereditary disorder
- coronary artery disease
- microcephalic primordial dwarfism
- autosomal recessive primary microcephaly type 10
- celiac disease
- abdominal aortic aneurysm
- microcephaly
- deficiency of aminoacyclase 1
- aneurysm
role in cell
- proliferation
- expression in
- differentiation
- cell survival
- morphogenesis
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp335 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- positive regulation of lymphocyte proliferation
- neuron projection morphogenesis
- positive regulation of neuroblast proliferation
- brain morphogenesis
- positive regulation of neurogenesis
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of gene expression, epigenetic
- cerebral cortex neuron differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone methyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding