ZNF335 Gene Summary [Human]
The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZNF335 |
| Official Name | zinc finger protein 335 [Source:HGNC Symbol;Acc:HGNC:15807] |
| Ensembl ID | ENSG00000198026 |
| Bio databases IDs | |
| Aliases | zinc finger protein 335, NRC-interacting factor 1 |
| Synonyms | 1810045J01Rik, LOC102554906, MCPH10, Nif, NIF-1, Zfp335, Zinc finger protein 335 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF335 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- transcription co-activator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- enzyme binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- hereditary disorder
- coronary artery disease
- microcephalic primordial dwarfism
- autosomal recessive primary microcephaly type 10
- celiac disease
- abdominal aortic aneurysm
- microcephaly
- deficiency of aminoacyclase 1
- aneurysm
role in cell
- proliferation
- expression in
- differentiation
- cell survival
- morphogenesis
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF335 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- positive regulation of lymphocyte proliferation
- neuron projection morphogenesis
- positive regulation of neuroblast proliferation
- brain morphogenesis
- positive regulation of neurogenesis
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of gene expression, epigenetic
- cerebral cortex neuron differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone methyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding