Sox13 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including gamma-delta T cell differentiation; positive regulation of cell differentiation; and spinal cord oligodendrocyte cell differentiation. Acts upstream of or within regulation of gamma-delta T cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hair follicle. Orthologous to human SOX13 (SRY-box transcription factor 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sox13 |
| Official Name | SRY (sex determining region Y)-box 13 [Source:MGI Symbol;Acc:MGI:98361] |
| Ensembl ID | ENSMUSG00000070643 |
| Bio databases IDs | |
| Aliases | SRY (sex determining region Y)-box 13 |
| Synonyms | ICA12, SRY-box transcription factor 13, SRY (sex determining region Y)-box 13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sox13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- high mobility group (HMG)-box domain superfamily
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- transcription factor activity
Pathways
Biological processes and signaling networks where the Sox13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- side effect
- growth failure
- skin basal cell carcinoma
- basal cell skin cancer
role in cell
- migration
- proliferation
- number
- transactivation in
- differentiation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sox13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of brown fat cell differentiation
- negative regulation of transcription, DNA-dependent
- gamma-delta T cell differentiation
- spinal cord oligodendrocyte cell differentiation
- cell fate commitment
- positive regulation of gamma-delta T cell differentiation
- regulation of transcription, DNA-dependent
- anatomical structure morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity