Cmtm8 Gene Summary [Mouse]
Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in nucleoplasm. Predicted to be active in membrane. Is expressed in several structures, including adenohypophysis; gut; nasal cavity epithelium; respiratory system; and ventricular layer. Orthologous to human CMTM8 (CKLF like MARVEL transmembrane domain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmtm8 |
| Official Name | CKLF-like MARVEL transmembrane domain containing 8 [Source:MGI Symbol;Acc:MGI:2447167] |
| Ensembl ID | ENSMUSG00000041012 |
| Bio databases IDs | |
| Aliases | CKLF-like MARVEL transmembrane domain containing 8 |
| Synonyms | 2700018N07Rik, CKLF-like MARVEL transmembrane domain containing 8, CKLFSF8, CKLFSF8-V2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cmtm8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- femoral hernia
- bipolar disorder
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- expression in
- activation in
- signaling in
- migration
- morphology
- motility
- invasion
- epithelial to mesenchymal transdifferentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cmtm8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- signal transduction
- myelination
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- structural constituent of myelin sheath