Otud3 Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in cellular response to nutrient levels; protein deubiquitination; and protein stabilization. Predicted to act upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; protein K27-linked deubiquitination; and protein K48-linked deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in axial skeleton; olfactory epithelium; pancreas; and vomeronasal organ. Orthologous to human OTUD3 (OTU deubiquitinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otud3 |
| Official Name | OTU domain containing 3 [Source:MGI Symbol;Acc:MGI:1920412] |
| Ensembl ID | ENSMUSG00000041161 |
| Bio databases IDs | |
| Aliases | OTU domain containing 3 |
| Synonyms | 3110030K17RIK, DUBA4, OTU deubiquitinase 3, OTU domain containing 3, RGD1560468 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Otud3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ovarian tumor domain
- peptidase
- ubiquitin-specific protease
- protein binding
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- organismal death
- ulcerative colitis
- inflammatory bowel disease
- liver cancer
- breast cancer
- metastasis
- advanced cancer
- tumorigenesis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
regulated by
- OTUD3
- nicotine
role in cell
- expression in
- phosphorylation in
- proliferation
- growth
- degradation in
- ubiquitination in
- binding in
- deubiquitination in
- polyubiquitination in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Otud3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked deubiquitination
- cellular response to nutrient levels
- proteolysis
- protein K6-linked deubiquitination
- protein stabilization
- protein K48-linked deubiquitination
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding