Dgka Gene Summary [Mouse]
Enables ATP-dependent diacylglycerol kinase activity and phospholipid binding activity. Predicted to be involved in glycerolipid metabolic process; intracellular signal transduction; and lipid phosphorylation. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; integumental system; respiratory system; and sensory organ. Orthologous to human DGKA (diacylglycerol kinase alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgka |
| Official Name | diacylglycerol kinase, alpha [Source:MGI Symbol;Acc:MGI:102952] |
| Ensembl ID | ENSMUSG00000025357 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase, alpha |
| Synonyms | Alpha diacylglycerol kinase, DAGK, DAGK1, Dagk α, DGK-alpha, DGK-α, diacylglycerol kinase alpha, diacylglycerol kinase, alpha, diacylglycerol kinase α, diacylglycerol kinase, α, α diacylglycerol kinase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgka often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- EF-hand, calcium binding motif
- lipid binding
- diacylglycerol kinase
- EF-hand domain pair
- EFh
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- kinase domain
- Diacylglycerol kinase N-terminus
- EF hand
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Diacylglycerol kinase catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- metastasis
- organismal death
- esophageal squamous cell cancer
- esophageal squamous cell carcinoma
- localized aggressive periodontitis
- colon cancer
role in cell
- phosphorylation in
- expression in
- activation in
- survival
- invasion by
- proliferation
- production in
- migration
- growth
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Plasma Membrane
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgka gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerolipid metabolic process
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- phosphatidic acid biosynthetic process
- lipid phosphorylation
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium ion binding
- lipid binding
- diacylglycerol kinase activity
- phospholipid binding
- alkylglycerol kinase activity
- kinase activity