Zmiz2 Gene Summary [Mouse]
Predicted to enable SUMO ligase activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to be located in mitochondrion; nuclear replication fork; and nucleoplasm. Predicted to be active in chromatin. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ZMIZ2 (zinc finger MIZ-type containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zmiz2 |
| Official Name | zinc finger, MIZ-type containing 2 [Source:MGI Symbol;Acc:MGI:106374] |
| Ensembl ID | ENSMUSG00000041164 |
| Bio databases IDs | |
| Aliases | zinc finger, MIZ-type containing 2 |
| Synonyms | hZIMP7, LOC103693776, NET27, RGD1309256, TRAFIP20, ZIMP7, zinc finger MIZ-type containing 2, zinc finger, MIZ-type containing 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zmiz2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- MIZ/SP-RING zinc finger
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- pervasive developmental disorder
role in cell
- growth
- expression in
- proliferation
- phosphorylation in
- invasion by
- migration
- cell cycle progression
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zmiz2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- SMAD protein signal transduction
- transforming growth factor beta receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- nuclear replication fork
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity