Opn1sw Gene Summary [Mouse]
Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to UV-A; and phototransduction. Located in cone photoreceptor outer segment. Is expressed in several structures, including brain; genitourinary system; gut; liver and biliary system; and retina. Human ortholog(s) of this gene implicated in blue color blindness. Orthologous to human OPN1SW (opsin 1, short wave sensitive). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Opn1sw |
| Official Name | opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) [Source:MGI Symbol;Acc:MGI:99438] |
| Ensembl ID | ENSMUSG00000058831 |
| Bio databases IDs | |
| Aliases | opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) |
| Synonyms | BCP, BLUE CONE OPSIN, BLUE OPSIN, BOP, CBT, opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan), opsin 1, short wave sensitive, S-opsin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Opn1sw often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- signaling receptor activity
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Opn1sw gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- Axonal Guidance Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- Chemokine Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- fMLP Signaling in Neutrophils
- Gap Junction Signaling
- GNRH Signaling
- Gαi Signaling
- IL-4 Signaling
- IL-8 Signaling
- Leukocyte Extravasation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- Protein Kinase A Signaling
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Sphingosine-1-phosphate Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- tritan colorblindness
- cholangiocarcinoma cancer
regulates
- HAMP
- CYP
role in cell
- growth
- survival
- replication in
- endoplasmic reticulum stress response
- cisplatin sensitivity
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- cytoplasmic bridges
- cytosol
- nucleoplasm
- photoreceptor outer segments
- cellular protrusions
- perikaryon
- axon terminals
- cone outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Opn1sw gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to light stimulus
- cellular response to UV-A
- G-protein coupled receptor signaling pathway
- detection of visible light
- signal transduction
- visual perception
- phototransduction
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- perinuclear region of cytoplasm
- cytosol
- photoreceptor inner segment
- plasma membrane
- nucleoplasm
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- G-protein coupled photoreceptor activity