Iapp Gene Summary [Mouse]
Predicted to enable hormone activity; identical protein binding activity; and lipid binding activity. Acts upstream of or within negative regulation of bone resorption; negative regulation of osteoclast differentiation; and sensory perception of pain. Located in extracellular space. Is expressed in embryo; pancreas; pancreas primordium; and pancreas trunk epithelium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iapp |
| Official Name | islet amyloid polypeptide [Source:MGI Symbol;Acc:MGI:96382] |
| Ensembl ID | ENSMUSG00000041681 |
| Bio databases IDs | |
| Aliases | islet amyloid polypeptide |
| Synonyms | Amylin, Amylin precursor, DAP, IAP, islet amyloid polypeptide |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iapp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- calcitonin
- hormone
- receptor agonist activity
- protein binding
- receptor binding
- beta-amyloid binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Alzheimer disease
- osteoporosis
- non-insulin-dependent diabetes mellitus
- weight loss
- weight gain
- thymus cancer
- lymphoid cancer
- mediastinal cancer
- lymphatic neoplasia
role in cell
- phosphorylation in
- expression in
- quantity
- proliferation
- activation in
- production in
- differentiation
- apoptosis
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
- cytosol
- mitochondrial cristae
- insulin secretory granules
- secretory granules
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Iapp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell-cell signaling
- positive regulation of MAPK cascade
- negative regulation of bone resorption
- eating behavior
- osteoclast differentiation
- positive regulation of calcium-mediated signaling
- positive regulation of protein kinase A signaling cascade
- bone resorption
- negative regulation of osteoclast differentiation
- positive regulation of apoptotic process
- apoptotic process
- negative regulation of protein complex assembly
- sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding
- receptor agonist activity
- receptor binding
- hormone activity
- beta-amyloid binding