Dlgap3 Gene Summary [Mouse]
Enables amyloid-beta binding activity. Involved in modification of postsynaptic structure and modulation of chemical synaptic transmission. Located in synapse. Is active in several cellular components, including cholinergic synapse; glutamatergic synapse; and neuromuscular junction. Is expressed in corpus striatum. Orthologous to human DLGAP3 (DLG associated protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlgap3 |
| Official Name | DLG associated protein 3 [Source:MGI Symbol;Acc:MGI:3039563] |
| Ensembl ID | ENSMUSG00000042388 |
| Bio databases IDs | |
| Aliases | DLG associated protein 3 |
| Synonyms | DAP-3, DLG associated protein 3, PRPL8, SAPAP3, SPAPA3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlgap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein domain specific binding
- protein binding
- beta-amyloid binding
- PDZ binding motif
- Guanylate-kinase-associated protein (GKAP) protein
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- androgenic alopecia
- overgrooming
- alopecia
role in cell
- expression in
- development
- quantity
- synaptic depression
- endocytosis by
- synaptic transmission in
- synaptic depression in
- synaptic transmission
- excitatory postsynaptic potential
- synaptic plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- organelle
- cellular membrane
- Plasma Membrane
- dendritic spines
- neuromuscular junctions
- synapse
- perikaryon
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlgap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signaling
- regulation of synaptic transmission
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- neuromuscular junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-amyloid binding
- binding, bridging