Ccno Gene Summary [Mouse]
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within several processes, including cilium assembly; seminiferous tubule development; and spermatogenesis. Located in cytoplasm. Is expressed in brain; nasal epithelium; reproductive system; and trachea. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 29. Orthologous to human CCNO (cyclin O). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccno |
| Official Name | cyclin O [Source:MGI Symbol;Acc:MGI:2145534] |
| Ensembl ID | ENSMUSG00000042417 |
| Bio databases IDs | |
| Aliases | cyclin O |
| Synonyms | CCNU, CILD29, cyclin O, E130318K11, RGD1565217, UDG2, Ung2, URACIL DNA GLYCOSYLASE 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccno often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclin box fold superfamily
- Cyclin, N-terminal domain
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- transitional cell bladder cancer
- urothelial bladder carcinoma
- primary ciliary dyskinesia
- epithelial cancer
- primary ciliary dyskinesia type 29
- lung squamous cell carcinoma
- squamous cell lung cancer
- liver cancer
- hepatocellular carcinoma
- renal cell cancer
regulates
- CENPA
- cytosine
role in cell
- proliferation
- differentiation
- assembly
- induction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- Cytoplasm
- centrosome
- nucleoli
- DNA replication foci
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccno gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cilium morphogenesis
- response to xenobiotic stimulus
- mitotic cell cycle
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- centriolar satellite
- cyclin-dependent protein kinase holoenzyme complex
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- cyclin-dependent protein kinase regulator activity