Sh2b3 Gene Summary [Mouse]
This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Sh2b3 |
| Official Name | SH2B adaptor protein 3 [Source:MGI Symbol;Acc:MGI:893598] |
| Ensembl ID | ENSMUSG00000042594 |
| Bio databases IDs | |
| Aliases | SH2B adaptor protein 3 |
| Synonyms | IDDM20, LNK, SH2B adaptor protein 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh2b3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stem cell factor receptor binding
- binding protein
- protein kinase binding
- receptor signaling complex scaffold protein
- Phenylalanine zipper
- Src homology 2 (SH2) domain
- protein binding
- Pleckstrin homology-like domain
- phosphate binding
Pathways
Biological processes and signaling networks where the Sh2b3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- coronary artery disease
- hypertension
- primary biliary cirrhosis
- insulin-dependent diabetes mellitus
- lung squamous cell carcinoma
- tumorigenesis
- renal cancer
- lung cancer
- metastasis
role in cell
- activation in
- cell death
- phosphorylation in
- expression in
- number
- proliferation
- migration
- invasion by
- adhesion
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh2b3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of response to cytokine stimulus
- negative regulation of MAPK cascade
- embryonic hemopoiesis
- negative regulation of platelet aggregation
- negative regulation of cell proliferation
- hemopoietic stem cell differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- erythrocyte development
- thrombopoietin-mediated signaling pathway
- negative regulation of Kit signaling pathway
- neutrophil homeostasis
- negative regulation of JAK-STAT cascade
- negative regulation of chemokine-mediated signaling pathway
- megakaryocyte development
- monocyte homeostasis
- cellular response to interleukin-3
- intracellular signal transduction
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- stem cell factor receptor binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- receptor signaling complex scaffold activity