Nkrf Gene Summary [Mouse]
Predicted to enable ATPase activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in nucleolus and nucleoplasm. Is expressed in limb mesenchyme and ureter. Orthologous to human NKRF (NFKB repressing factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkrf |
| Official Name | NF-kappaB repressing factor [Source:MGI Symbol;Acc:MGI:1924536] |
| Ensembl ID | ENSMUSG00000044149 |
| Bio databases IDs | |
| Aliases | NF-kappaB repressing factor |
| Synonyms | 9430034D17RIK, AW124770, C80287, ITBA4, NF-kappaB repressing factor, NFKB repressing factor, NRF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkrf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- ATPase stimulator
- transcription regulator
- G-patch domain
- R3H
- Double-stranded RNA binding motif
- nucleic acid binding
- R3H domain
- double-stranded DNA binding
- double-stranded RNA binding motif (DSRM) superfamily
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Klinefelter syndrome
- preeclampsia
role in cell
- expression in
- activation in
- production in
- survival
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkrf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- ATPase activator activity