Fads3 Gene Summary [Mouse]
Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Acts upstream of or within gene expression and unsaturated fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in nervous system; retina; and thoracic segment skeleton. Orthologous to human FADS3 (fatty acid desaturase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fads3 |
| Official Name | fatty acid desaturase 3 [Source:MGI Symbol;Acc:MGI:1928740] |
| Ensembl ID | ENSMUSG00000024664 |
| Bio databases IDs | |
| Aliases | fatty acid desaturase 3 |
| Synonyms | CYB5RP, fatty acid desaturase 3, LLCDL3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fads3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-FADS-like
- Fatty acid desaturase
- Cytochrome b5-like Heme/Steroid binding domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- breast cancer
- organismal death
- systemic lupus erythematosus
regulates
- polyunsaturated fatty acids
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fads3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- unsaturated fatty acid biosynthetic process
- lipid metabolic process
- sphingolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water