Plppr4 Gene Summary [Mouse]
Predicted to enable lysophosphatidic acid phosphatase activity and phosphatidate phosphatase activity. Involved in lipid import into cell; regulation of glutamatergic synaptic transmission; and regulation of postsynapse organization. Acts upstream of or within inner ear development. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in genitourinary system; retina; and telencephalon. Orthologous to human PLPPR4 (phospholipid phosphatase related 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plppr4 |
| Official Name | phospholipid phosphatase related 4 [Source:MGI Symbol;Acc:MGI:106530] |
| Ensembl ID | ENSMUSG00000044667 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase related 4 |
| Synonyms | A330086D10, D3Bwg0562e, KIAA0455, LPPR4, LPR4, mKIAA0455, phospholipid phosphatase related 4, PHP1, PRG-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plppr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- lipid phosphatase
- PAP2 superfamily
- phosphatidate phosphatase
- phosphatase
- protein binding
- PAP2_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- bacterial meningitis
- thermal hyperalgesia
- endometrial carcinoma
- epithelial endometrial cancer
- diabetic nephropathy
regulates
- phospholipid
role in cell
- replication in
- growth
- inactivation
- development
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- plasma membrane extracellular face
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plppr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- inner ear development
- G-protein coupled receptor signaling pathway
- signal transduction
- axonogenesis
- phospholipid metabolic process
- regulation of synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- lysophosphatidic acid phosphatase activity