Tcf21 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and E-box binding activity. Involved in several processes, including metanephros development; regulation of transcription by RNA polymerase II; and skeletal muscle organ development. Acts upstream of or within several processes, including lung development; nephron development; and sex determination. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart and pericardium; and respiratory system. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcf21 |
| Official Name | transcription factor 21 [Source:MGI Symbol;Acc:MGI:1202715] |
| Ensembl ID | ENSMUSG00000045680 |
| Bio databases IDs | |
| Aliases | transcription factor 21 |
| Synonyms | bHLHa23, Capsulin, epc, epicardin, Msf-1, POD1, transcription factor 21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcf21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- androgen receptor binding
- transcription factor binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
Pathways
Biological processes and signaling networks where the Tcf21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- uterine serous papillary cancer
- dyspnea
- diabetic nephropathy
- hypoplasia
- metastatic colorectal cancer
- sex reversal
- cyanosis
- prostate cancer
phenotypes
- abnormal branching involved in lung morphogenesis
- abnormal branching involved in ureteric bud morphogenesis
- abnormal glomerular capillary morphology
- abnormal heart apex morphology
- abnormal heart morphology
- abnormal heart shape
- abnormal kidney blood vessel morphology
- abnormal kidney development
- abnormal kidney medulla morphology
- abnormal kidney mesenchyme morphology
- abnormal lung epithelium morphology
- abnormal lung vasculature morphology
- abnormal ovary morphology
- abnormal ovary topology
- abnormal peritubular capillary morphology
- abnormal podocyte foot process morphology
- abnormal podocyte morphology
- abnormal proximal convoluted tubule morphology
- abnormal pulmonary acinus morphology
- abnormal pulmonary alveolar sac morphology
- abnormal renal glomerulus morphology
- abnormal spleen development
- abnormal ureteric bud morphology
- abnormal ureteric bud tip morphology
- absent proximal convoluted tubule brush border
- absent pulmonary alveoli
- absent spleen
- absent type II pneumocytes
- cyanosis
- decreased nephron number
- decreased renal glomerulus number
- delayed kidney development
- dilated respiratory conducting tubes
- disorganized testis cords
- ectopic ovary
- enlarged heart right atrium
- hemopericardium
- impaired branching involved in alveolar sac morphogenesis
- impaired branching involved in bronchus morphogenesis
- impaired branching involved in ureteric bud morphogenesis
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- pallor
- primary sex reversal
- pulmonary hypoplasia
- renal glomerulus atrophy
- renal hypoplasia
- respiratory distress
- respiratory failure
- secondary sex reversal
- sex reversal
- small gonad
- small kidney
- small lung
- small lung lobe
- thin myocardium
role in cell
- expression in
- apoptosis
- differentiation
- degradation in
- deposition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcf21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory system development
- palate development
- Sertoli cell differentiation
- lung vasculature development
- spleen development
- embryonic digestive tract morphogenesis
- sex determination
- gland development
- positive regulation of transcription from RNA polymerase II promoter
- lung morphogenesis
- negative regulation of androgen receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- morphogenesis of a branching structure
- lung alveolus development
- metanephric mesenchymal cell differentiation
- kidney development
- vasculature development
- developmental process
- reproductive structure development
- diaphragm development
- bronchiole development
- regulation of transcription from RNA polymerase II promoter
- epithelial cell differentiation
- glomerulus development
- ureteric bud development
- branchiomeric skeletal muscle development
- metanephric glomerular capillary formation
- branching involved in ureteric bud morphogenesis
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- androgen receptor binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- bHLH transcription factor binding
- E-box binding