Ppm1e Gene Summary [Mouse]
Predicted to enable protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; bone; central nervous system; retina; and spleen. Orthologous to human PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppm1e |
| Official Name | protein phosphatase 1E (PP2C domain containing) [Source:MGI Symbol;Acc:MGI:2444096] |
| Ensembl ID | ENSMUSG00000046442 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1E (PP2C domain containing) |
| Synonyms | B930008A12Rik, caMKN, CAMKPN, mKIAA1072, POPX1, PP2CH, protein phosphatase 1E (PP2C domain containing), protein phosphatase, Mg2+/Mn2+ dependent 1E, protein phosphatase, Mg2+/Mn2+ dependent, 1E |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppm1e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein phosphatase 2C
- catalytic domain
- protein serine/threonine phosphatase
- phosphoprotein phosphatase
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Pathways
Biological processes and signaling networks where the Ppm1e gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- chronic lymphocytic leukemia
- pervasive developmental disorder
role in cell
- morphology
- assembly
- response
- breakdown
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppm1e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- cellular response to lipopolysaccharide
- positive regulation of stress fiber assembly
- protein dephosphorylation
- cellular response to xenobiotic stimulus
- negative regulation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity