CD300LF Gene Summary [Human]
This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | CD300LF |
| Official Name | CD300 molecule like family member f [Source:HGNC Symbol;Acc:HGNC:29883] |
| Ensembl ID | ENSG00000186074 |
| Bio databases IDs | |
| Aliases | CD300 molecule like family member f |
| Synonyms | CD300f, CD300 molecule like family member F, CLIM1, CLM-1, Digr2, F730004D16Rik, IgSF13, IREM-1, LMIR3, NKIR, Pigr3, RGD1309733 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD300LF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- SHP2-interacting transmembrane adaptor protein, SIT
- extracellular domain
- sphingolipid binding
- viral receptor
- interleukin-4 receptor binding
- immunoglobulin domain
- protein binding
- identical protein binding
- binding protein
- immunoreceptor tyrosine-based inhibition motif
- transmembrane domain
- Immunoglobulin like
- cytosolic tail domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- experimentally induced airway hyperresponsiveness
- coronary artery disease
- anhedonia
- hypersensitivity reaction type I
- demyelination
- passive cutaneous anaphylaxis
- dermatitis
- infection by Murine norovirus
role in cell
- production in
- expression in
- activation in
- activity
- function
- activation
- synthesis in
- phosphorylation in
- differentiation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- apical cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD300LF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-13-mediated signaling pathway
- positive regulation of apoptotic cell clearance
- negative regulation of apoptotic cell clearance
- negative regulation of mast cell activation
- negative regulation of MyD88-dependent toll-like receptor signaling pathway
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ceramide binding
- phosphatidylserine binding
- identical protein binding
- protein binding
- transmembrane signaling receptor activity
- interleukin-4 receptor binding