Rapgef4 Gene Summary [Mouse]
Enables several functions, including cAMP binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Involved in positive regulation of insulin secretion and regulation of synaptic vesicle cycle. Acts upstream of or within with a positive effect on hormone secretion. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Is active in cytosol and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including adrenal gland; ganglia; heart; lung; and metanephros. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rapgef4 |
| Official Name | Rap guanine nucleotide exchange factor (GEF) 4 [Source:MGI Symbol;Acc:MGI:1917723] |
| Ensembl ID | ENSMUSG00000049044 |
| Bio databases IDs | |
| Aliases | Rap guanine nucleotide exchange factor (GEF) 4 |
| Synonyms | 1300003D15Rik, 5730402K07Rik, 6330581N18Rik, CAMP-GEFII, CAMPS, CGEF2, EPAC, EPAC 2, mKIAA4040, Nbla00496, Rap guanine nucleotide exchange factor 4, Rap guanine nucleotide exchange factor (GEF) 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rapgef4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- protein binding activity, bridging
- enzyme binding
- protein binding
- RasGEF
- Cyclic nucleotide-monophosphate binding domain
- DEP
- Cyclic nucleotide-binding domain
- binding protein
- 3',5'-cAMP binding
- guanyl-nucleotide exchange factor
- REM
- CAP_ED
Pathways
Biological processes and signaling networks where the Rapgef4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizophrenia
- ventricular tachycardia
- Moyamoya disease
- autosomal recessive polycystic kidney disease
- glioblastoma
- glioblastoma cancer
role in cell
- migration
- quantity
- activation in
- long-term potentiation
- apoptosis
- expression in
- cell viability
- differentiation
- assembly
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- presynaptic regions
- cellular membrane
- filamentous network
- Plasma Membrane
- cytosol
- apical membrane
- basolateral membrane
- dendritic spines
- growth cone
- neurites
- nerve ending
- synaptosomes
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- brush border
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- excitatory synapses
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rapgef4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin secretion
- G-protein coupled receptor signaling pathway
- adaptive immune response
- Ras protein signal transduction
- calcium ion-dependent exocytosis
- regulation of exocytosis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of insulin secretion
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- cAMP binding
- protein binding, bridging