Gpr3 Gene Summary [Mouse]
Predicted to enable sphingosine-1-phosphate receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within regulation of meiotic nuclear division. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; eye; gonad; and salivary gland. Orthologous to human GPR3 (G protein-coupled receptor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr3 |
| Official Name | G-protein coupled receptor 3 [Source:MGI Symbol;Acc:MGI:101908] |
| Ensembl ID | ENSMUSG00000049649 |
| Bio databases IDs | |
| Aliases | G-protein coupled receptor 3 |
| Synonyms | ACCA, Gpcr20, Gpcr21, GPCR3, G protein-coupled receptor 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- metabolic disorder
role in cell
- expression in
- growth
- maturation
- outgrowth
- energy expenditure
- meiosis
- abnormal morphology
- compaction
- production in
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- perinuclear space
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of meiosis
- cytosolic calcium ion homeostasis
- regulation of metabolic process
- positive regulation of cAMP-mediated signaling
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding