Ch25h Gene Summary [Mouse]
Enables cholesterol 25-hydroxylase activity. Involved in B cell chemotaxis and negative regulation of cholesterol metabolic process. Acts upstream of or within cholesterol metabolic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; respiratory system; and skin. Orthologous to human CH25H (cholesterol 25-hydroxylase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ch25h |
| Official Name | cholesterol 25-hydroxylase [Source:MGI Symbol;Acc:MGI:1333869] |
| Ensembl ID | ENSMUSG00000050370 |
| Bio databases IDs | |
| Aliases | cholesterol 25-hydroxylase |
| Synonyms | 25-Hydroxylase, C25H, cholesterol 25-hydroxylase, m25OH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ch25h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fatty acid hydroxylase
- cholesterol 25-hydroxylase
- enzyme
- protein binding
- steroid hydroxylase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- gout
- survival
- organismal death
- knee osteoarthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
role in cell
- expression in
- response
- production in
- activation
- cellular infiltration by
- phagocytosis by
- chemotaxis by
- recruitment in
- metabolism in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ch25h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cholesterol metabolic process
- lipid metabolic process
- response to type I interferon
- cholesterol metabolic process
- B cell chemotaxis
- sterol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- C-4 methylsterol oxidase activity
- protein binding
- cholesterol 25-hydroxylase activity
- iron ion binding
- steroid hydroxylase activity