Ccr4 Gene Summary [Mouse]
Enables C-C chemokine receptor activity. Acts upstream of or within several processes, including homeostasis of number of cells; interneuron migration; and tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; gut; limb; liver and biliary system; and reproductive system. Orthologous to human CCR4 (C-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr4 |
| Official Name | chemokine (C-C motif) receptor 4 [Source:MGI Symbol;Acc:MGI:107824] |
| Ensembl ID | ENSMUSG00000047898 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 4 |
| Synonyms | C-C CKR-4, C-C motif chemokine receptor 4, CCR4 receptor, CD194, CHEMOKINE CC4 receptor, CHEMR1, ChemR13, CKR4, CMKBR4, HGCN:14099, K5-5, LESTR, nocturnin, Sdf1r |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccr4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- atopic dermatitis
- recurrent cutaneous T-cell lymphoma
- experimental autoimmune encephalomyelitis
- multiple sclerosis
- mycosis fungoides
- Sézary syndrome
- rheumatoid arthritis
- obesity
role in cell
- phosphorylation in
- growth
- quantity
- activation in
- migration
- mobilization in
- chemotaxis
- cellular infiltration by
- number
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- response to bacterium
- inflammatory response
- immune response
- chemokine-mediated signaling pathway
- homeostasis of number of cells
- positive regulation of positive chemotaxis
- tolerance induction
- calcium-mediated signaling
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- protein binding
- C-C chemokine receptor activity
- chemokine receptor activity