Prok1 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within positive regulation of MAPK cascade; positive regulation of vascular endothelial cell proliferation; and regulation of angiogenesis. Located in extracellular region. Is expressed in embryo; liver; lung; metanephros; and testis. Orthologous to human PROK1 (prokineticin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prok1 |
| Official Name | prokineticin 1 [Source:MGI Symbol;Acc:MGI:2180370] |
| Ensembl ID | ENSMUSG00000070368 |
| Bio databases IDs | |
| Aliases | prokineticin 1 |
| Synonyms | EG-VEGF, PK1, PRK1, prokineticin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prok1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins
- G-protein-coupled receptor binding
- Prokineticin
- growth factor
Pathways
Biological processes and signaling networks where the Prok1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Bladder Cancer Signaling
- Clathrin-mediated Endocytosis Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Estrogen Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-17 Signaling
- IL-8 Signaling
- ILK Signaling
- mTOR Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- TR/RXR Activation
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- heart failure
regulated by
- lipopolysaccharide
- Bvht
- doxorubicin
role in cell
- proliferation
- expression in
- phosphorylation in
- migration
- apoptosis
- production in
- quantity
- permeability
- survival
- sprouting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prok1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell division
- signal transduction
- angiogenesis
- endothelial cell proliferation
- regulation of angiogenesis
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity