Gen1 Gene Summary [Mouse]
Predicted to enable several functions, including DNA endonuclease activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA metabolic process and regulation of cell cycle process. Predicted to be located in centrosome. Is expressed in embryo; heart; metanephros; nephric duct; and neural tube. Orthologous to human GEN1 (GEN1 Holliday junction 5' flap endonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gen1 |
| Official Name | GEN1, Holliday junction 5' flap endonuclease [Source:MGI Symbol;Acc:MGI:2443149] |
| Ensembl ID | ENSMUSG00000051235 |
| Bio databases IDs | |
| Aliases | GEN1, Holliday junction 5' flap endonuclease |
| Synonyms | 5830483C08Rik, FLJ40869, Gen, GEN1 Holliday junction 5' flap endonuclease, GEN1, Holliday junction 5' flap endonuclease, LOC284952, RGD1559792 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gen1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA secondary structure binding
- Xeroderma pigmentosum G I-region
- XPG I-region
- enzyme
- flap endonuclease
- XPG N-terminal domain
- magnesium ion binding
- Chromatin organization modifier domain 2
- crossover junction endoribonuclease
- H3TH_StructSpec-5'-nucleases
- protein homodimerization
- Xeroderma pigmentosum G N-region
- PIN (PilT N terminus) domain: Superfamily
Pathways
Biological processes and signaling networks where the Gen1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- familial ovarian cancer
- familial breast carcinoma
- breast carcinoma
- familial breast cancer
regulates
role in cell
- activation in
- formation
- morphology
- formation in
- S phase
- elongation
- segregation
- elongation in
- segregation in
- movement in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gen1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- resolution of mitotic recombination intermediates
- regulation of centrosome duplication
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- double-strand break repair via homologous recombination
- resolution of recombination intermediates
- replication fork processing
Cellular Component
Where in the cell the gene product is active
- centrosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- 5'-flap endonuclease activity
- protein homodimerization activity
- four-way junction DNA binding
- crossover junction endodeoxyribonuclease activity