Spn

Enables heat shock protein binding activity. Involved in leukocyte tethering or rolling; negative regulation of T cell proliferation; and positive regulation of T cell migration. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; regulation of T cell activation; and regulation of defense response. Located in basement membrane; external side of plasma membrane; and uropod. Is expressed in hematopoietic system; umbilical artery; vascular system; and yolk sac. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Spn gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Spn gene, providing context for its role in the cell.