Senp7 Gene Summary [Mouse]
This gene encodes a SUMO deconjugating enzyme of the Sentrin/SUMO-specific protease (SENP) family. The encoded protein is a protease that exhibits deSUMOylating activity towards proteins involved in chromatin remodeling and promotes chromatin relaxation for DNA repair or transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Details
| Type | Processed Transcript |
| Official Symbol | Senp7 |
| Official Name | SUMO1/sentrin specific peptidase 7 [Source:MGI Symbol;Acc:MGI:1913565] |
| Ensembl ID | ENSMUSG00000052917 |
| Bio databases IDs | |
| Aliases | SUMO1/sentrin specific peptidase 7 |
| Synonyms | 2410152H17Rik, 2810413I22RIK, 2900036C23RIK, 6030449K19Rik, SSP2, SUMO1/sentrin specific peptidase 7, SUMO specific peptidase 7, SUSP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Senp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- catalytic domain
- Ulp1 protease family, C-terminal catalytic domain
- peptidase
- protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Senp7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- myeloproliferative disorder
- COVID-19
- breast cancer
- dermatological disorder
- actinic keratosis
role in cell
- expression in
- proliferation
- degradation in
- production in
- size
- number
- quantity
- oxidative phosphorylation in
- glycolysis in
- sumoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Senp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein desumoylation
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SUMO-specific endopeptidase activity