Arhgef15 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of synapse maturation and regulation of postsynapse assembly. Acts upstream of or within retina vasculature morphogenesis in camera-type eye. Located in dendrite. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef15 |
| Official Name | Rho guanine nucleotide exchange factor (GEF) 15 [Source:MGI Symbol;Acc:MGI:3045246] |
| Ensembl ID | ENSMUSG00000052921 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF) 15 |
| Synonyms | ARGEF15, D130071N09, D530030K12Rik, E5, Ephexin5, Rho guanine nucleotide exchange factor 15, Vms-rhogef, Vsm-RhoGEF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- protein binding
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the Arhgef15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- bipolar disorder
- preeclampsia
- Ohtahara syndrome
- nonalcoholic fatty liver disease
- microscopic hematuria
regulates
role in cell
- maturation
- tubulation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cytosol
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina vasculature morphogenesis in camera-type eye
- regulation of small GTPase mediated signal transduction
- positive regulation of stress fiber assembly
- regulation of catalytic activity
- negative regulation of synapse maturation
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity