Bcl3 Gene Summary [Mouse]
Enables transcription coactivator activity. Acts upstream of or within several processes, including defense response to other organism; lymphocyte activation involved in immune response; and regulation of gene expression. Predicted to be located in several cellular components, including cytosol; midbody; and nucleoplasm. Predicted to be part of Bcl3-Bcl10 complex and Bcl3/NF-kappaB2 complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human BCL3 (BCL3 transcription coactivator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl3 |
| Official Name | B cell leukemia/lymphoma 3 [Source:MGI Symbol;Acc:MGI:88140] |
| Ensembl ID | ENSMUSG00000053175 |
| Bio databases IDs | |
| Aliases | B cell leukemia/lymphoma 3 |
| Synonyms | B CELL CLL/LYMPHOMA 3, B-cell leukaemia/lymphoma 3, B-cell leukemia/lymphoma 3, BCL3 transcription coactivator, BCL3, transcription coactivator, BCL4, D19S37, LOC105372417, LOC686871 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- transcription co-activator
- transcription co-repressor
- protein binding activity, bridging
- PVDLR motif
- Ankyrin repeats (3 copies)
- transcription factor binding
- histone deacetylase binding
- protein binding
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Bcl3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- asthma
- respiratory disorder
- gastroesophageal reflux
- splenomegaly
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- serous ovarian adenocarcinoma
- serous ovarian cancer
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
role in cell
- migration
- phosphorylation in
- number
- apoptosis
- expression in
- transcription in
- proliferation
- survival
- cellular infiltration by
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- Plasma Membrane
- basal bodies
- midbody
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- spleen development
- response to virus
- positive regulation of transcription from RNA polymerase II promoter
- defense response to protozoan
- humoral immune response mediated by circulating immunoglobulin
- regulation of DNA binding
- marginal zone B cell differentiation
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of interferon-gamma production
- negative regulation of tumor necrosis factor production
- negative regulation of NF-kappaB transcription factor activity
- T-helper 1 type immune response
- regulation of apoptotic process
- response to DNA damage stimulus
- I-kappaB kinase/NF-kappaB cascade
- defense response to bacterium
- negative regulation of JAK-STAT cascade
- follicular dendritic cell differentiation
- germinal center formation
- T-helper 2 cell differentiation
- negative regulation of T cell apoptotic process
- negative regulation of interleukin-8 production
- protein import into nucleus
- negative regulation of apoptotic process
- T cell apoptotic process
- DNA damage response, signal transduction by p53 class mediator
- extracellular matrix organization
- response to UV-C
- antimicrobial humoral response
- positive regulation of interleukin-10 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- Bcl3/NF-kappaB2 complex
- macromolecular complex
- midbody
- plasma membrane
- nucleoplasm
- Bcl3-Bcl10 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- transcription coactivator activity
- transcription corepressor activity
- protein binding, bridging