Dusp7 Gene Summary [Mouse]
Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade; peptidyl-tyrosine dephosphorylation; and signal transduction. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Orthologous to human DUSP7 (dual specificity phosphatase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp7 |
| Official Name | dual specificity phosphatase 7 [Source:MGI Symbol;Acc:MGI:2387100] |
| Ensembl ID | ENSMUSG00000053716 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 7 |
| Synonyms | DKFZP586F2224, dual specificity phosphatase 7, MKPX, protein TYROSINE PHOSPHATASE, PYST2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dusp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- protein tyrosine/serine/threonine phosphatase
- MAP kinase phosphatase
- protein-tyrosine-phoshatase
- Rhodanese Homology Domain
- phosphatase
- protein binding
- Rhodanese-like domain
- PTP_DSP_cys
- RHOD
Pathways
Biological processes and signaling networks where the Dusp7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
role in cell
- phosphorylation in
- proliferation
- activation in
- survival
- differentiation
- misalignment
- misalignment in
- pluripotency
- dephosphorylation in
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dusp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERK1 and ERK2 cascade
- MAPK cascade
- negative regulation of MAP kinase activity
- negative regulation of MAPK cascade
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- MAP kinase tyrosine phosphatase activity
- protein tyrosine/threonine phosphatase activity
- protein tyrosine phosphatase activity
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity