Alkal2 Gene Summary [Mouse]
Predicted to enable protein tyrosine kinase activator activity and signaling receptor binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of MAPK cascade; and positive regulation of neuron projection development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in brain. Orthologous to human ALKAL2 (ALK and LTK ligand 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alkal2 |
| Official Name | ALK and LTK ligand 2 [Source:MGI Symbol;Acc:MGI:3697448] |
| Ensembl ID | ENSMUSG00000054204 |
| Bio databases IDs | |
| Aliases | ALK and LTK ligand 2 |
| Synonyms | 6230419C23Rik, ALK and LTK ligand 2, AUGA, Augalpha, FAM150B, LOC686817, PRO1097, RGPG542 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alkal2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane receptor protein tyrosine kinase activator
- receptor tyrosine kinase binding
- protein binding
- cytokine
- receptor signaling protein tyrosine kinase activator
- growth factor
- FAM150 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- restless legs syndrome
- HER2 negative hormone receptor negative breast cancer
- refractive error
- obesity
- neoplastic cell transformation
role in cell
- activation in
- phosphorylation in
- growth
- differentiation
- tyrosine phosphorylation in
- colony formation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alkal2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ERK1 and ERK2 cascade
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of neuron projection development
- positive regulation of ERK5 cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane receptor protein tyrosine kinase activator activity
- receptor signaling protein tyrosine kinase activator activity
- cytokine activity
- receptor tyrosine kinase binding