Ltk Gene Summary [Mouse]
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Ltk |
| Official Name | leukocyte tyrosine kinase [Source:MGI Symbol;Acc:MGI:96840] |
| Ensembl ID | ENSMUSG00000027297 |
| Bio databases IDs | |
| Aliases | leukocyte tyrosine kinase |
| Synonyms | leukocyte receptor tyrosine kinase, leukocyte tyrosine kinase, TYK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ltk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Protein kinase (unclassified specificity)
- protein kinase
- YXXM motif
- Protein tyrosine and serine/threonine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- cytoplasmic domain
- transmembrane receptor protein tyrosine kinase
- transmembrane domain
- intracellular domain
- receptor signaling protein tyrosine kinase activator
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Ltk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- advanced lung squamous cell carcinoma
- metastatic non-small cell lung cancer
- advanced large cell lung carcinoma
- advanced non-small cell lung cancer
- non-small cell lung cancer
- metastatic lung adenocarcinoma
- ALK rearrangement positive non-small cell lung cancer
- latent tuberculosis
role in cell
- expression in
- phosphorylation in
- proliferation
- activation in
- apoptosis
- migration
- quantity
- polarization
- development
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ltk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- multicellular organismal development
- signal transduction
- peptidyl-tyrosine autophosphorylation
- transmembrane receptor protein tyrosine kinase signaling pathway
- regulation of neuron differentiation
- protein phosphorylation
- regulation of cell proliferation
- cellular response to retinoic acid
- negative regulation of apoptotic process
- positive regulation of cardiac muscle cell apoptotic process
- positive regulation of kinase activity
- positive regulation of neuron projection development
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- protein kinase activity
- receptor signaling protein tyrosine kinase activator activity